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[AIDS] latent cell에서 새로운 히스톤탈아세틸화 효소 억제제 metacept-1과 metacept-3의 HIV 전사 증가 효과
작성자
홍기종
작성일
2009-10-06
조회
1001
AIDS (24 September 2009 - Volume 23 - Issue 15 - p 2047-2050)

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

Shehu-Xhilaga, Miranda; Rhodes, David; Wightman, Fiona; Liu, Hong B; Solomon, Ajantha; Saleh, Suha; Dear, Anthony E; Cameron, Paul U; Lewin, Sharon R


We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.